Cedars-Sinai investigators have identified distinct genetic variants associated with resistant hypertension, a type of high blood pressure that remains uncontrolled despite medication. Their findings, ... At the 2026 ACC, researchers presented a meta-analysis of three trials (1,264 patients) assessing baxdrostat’s blood pressure and safety effects in uncontrolled hypertension.

Understanding the Context

More than one-quarter of patients with resistant hypertension had hypercortisolism, suggesting opportunities for screening, researchers reported at the American College of Cardiology Scientific ... The novel aldosterone synthase inhibitor baxdrostat has met its primary and secondary endpoints in the BaxHTN trial of patients with uncontrolled or treatment-resistant hypertension, according to ... Add Yahoo as a preferred source to see more of our stories on Google. Findings support sacubitril/valsartan's role as a potentially valuable late-line therapy for resistant hypertension.

Key Insights

Credit: ABO ... Monthly Prescribing Reference: Baxdrostat Lowers SBP in Patients With Uncontrolled, Resistant Hypertension Medscape: Study Suggests Lower Risk of Death in Patients With Resistant Hypertension (New York, New York) — An analysis from a large US database of patients with high blood pressure has shown that individuals with resistant hypertension have significantly elevated risks ...