hemophagocytosis - Viral Trends
Nature: Clinical significance of hemophagocytosis in BM clot sections during the peri-engraftment period following allogeneic hematopoietic SCT Clinical significance of hemophagocytosis in BM clot sections during the peri-engraftment period following allogeneic hematopoietic SCT Understand hemophagocytosis and hemophagocytic lymphohistiocytosis (HLH): triggers, diagnostic criteria, and current management strategies by Dr Moustafa Abdou. Hemophagocytosis is a dangerous form of phagocytosis in which histiocytes engulf red blood cells, white blood cells, platelets, and their precursors [1] in bone marrow and other tissues. It is part of the presentation of hemophagocytic lymphohistiocytosis and macrophage activation syndrome.
Understanding the Context
Hemophagocytosis is defined as the process by which macrophages engulf endogenous red blood cells, platelets, white blood cells, or their remnants, indicating hyperactivation of macrophages and potentially supporting a diagnosis of hemophagocytic lymphohistiocytosis (HLH). Hemophagocytosis describes a severe and potentially life-threatening immune response where immune cells, macrophages, become overactive. These cells then begin to destroy healthy blood cells, including red blood cells, white blood cells, and platelets. Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of defective apoptosis, a disruption of the regulatory pathway that terminates immune and inflammatory responses.
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Key Insights
Fever, cytopenia, splenomegaly, and/or hemophagocytosis are typical findings of ... what is hemophagocytosis? Hemophagocytosis is when macrophages eat blood cells (including erythrocytes, leukocytes, or platelets). This seems to reflect excessive inflammatory activation of macrophages. Hemophagocytosis is a histological hallmark of hemophagocytic lymphohistiocytosis.