The early symptoms of Wilson's disease can be subtle and vary depending on which parts of the body the disease affects. Early symptoms may include tiredness, loss of appetite, mood or personality changes, tremors, or trouble with coordination. Symptoms of Wilson disease vary a lot from person to person.

Understanding the Context

Wilson disease is present at birth (congenital), but the symptoms don’t appear until copper builds up in your liver, brain, eyes or other organs. People who have Wilson disease typically develop symptoms between ages 5 and 40. Some people do not have symptoms of Wilson disease before they are diagnosed with the disease and treated. If you do have symptoms, the symptoms may be related to your liver, nervous system and mental health, eyes, or other organs.

Key Insights

About half of people with Wilson's disease have neurological or psychiatric symptoms. Most initially have mild cognitive deterioration and clumsiness, as well as changes in behavior. Signs and Symptoms Often Seen in Patients with Wilson Disease If you need help in understanding what any of these terms are, please follow the hyperlinks to our glossary. In cases where Wilson's disease affects the liver, symptoms include: If the disease progresses, you may experience muscle cramps, jaundice, pain in the abdomen (belly) region, and spider... Symptoms can start at any age but in most cases they start between ages 5 and 35.

Final Thoughts

The symptoms of Wilson disease vary depending on the organs that are affected. Wilson disease may attack your brain and spinal cord (your central nervous system) and your liver. It may attack them at the same time. The symptoms of Wilson’s disease vary based on the organ system affected by the condition. Some of the primary parts of the body impacted include the liver, central nervous system, brain, and eyes. For adults with Wilson disease, patients “have more neuropsychiatric and movement symptoms—they experience tremors and personality changes,” said Dr.

Samant. Wilson's disease is a genetic disorder in which copper builds up in the body, mainly in the liver and brain. Without any treatment, the build-up of copper can cause serious symptoms. Treatment is with medication to remove the excess copper and/or to prevent a further build-up of copper.